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Calls › VRTX
VRTX Vertex Pharmaceuticals Incorporated · Healthcare

1 research call since Oct 22. Latest view: Lean bearish

Last close
$521.03 2026-10-27
1 week
+1.2%
1 month
-1.0%
3 months
+6.2%
1 year
+24.0%
Latest call vs SPY
-0.2% since 2026-10-21
Next earnings
2027-02-10 AMC
Technical scan
Strong Buy rank 11 of 127

Price, last 12 months daily close · markers are published calls

400.00450.00500.00550.002025-10-272026-04-292026-10-27Lean bearish · Oct 22, 20262025-10-27: 420.172025-10-28: 422.392025-10-29: 417.212025-10-30: 419.892025-10-31: 425.572025-11-03: 426.002025-11-04: 421.672025-11-05: 417.002025-11-06: 416.252025-11-07: 409.472025-11-10: 421.202025-11-11: 429.222025-11-12: 434.192025-11-13: 434.522025-11-14: 437.152025-11-17: 434.022025-11-18: 435.522025-11-19: 421.032025-11-20: 422.322025-11-21: 426.762025-11-24: 424.002025-11-25: 429.822025-11-26: 432.172025-11-28: 433.612025-12-01: 425.602025-12-02: 433.152025-12-03: 463.132025-12-04: 457.362025-12-05: 455.482025-12-08: 442.042025-12-09: 437.012025-12-10: 444.642025-12-11: 445.932025-12-12: 452.042025-12-15: 455.712025-12-16: 454.962025-12-17: 449.522025-12-18: 447.382025-12-19: 456.202025-12-22: 460.312025-12-23: 459.212025-12-24: 462.992025-12-26: 462.902025-12-29: 459.782025-12-30: 453.742025-12-31: 453.362026-01-02: 452.132026-01-05: 448.802026-01-06: 468.382026-01-07: 484.152026-01-08: 469.682026-01-09: 463.862026-01-12: 460.592026-01-13: 454.672026-01-14: 449.532026-01-15: 438.922026-01-16: 441.362026-01-20: 442.082026-01-21: 461.142026-01-22: 467.352026-01-23: 468.412026-01-26: 476.842026-01-27: 474.172026-01-28: 477.912026-01-29: 475.682026-01-30: 469.902026-02-02: 472.012026-02-03: 465.612026-02-04: 470.522026-02-05: 458.812026-02-06: 477.922026-02-09: 470.872026-02-10: 463.482026-02-11: 461.242026-02-12: 465.022026-02-13: 491.472026-02-17: 477.322026-02-18: 470.312026-02-19: 469.272026-02-20: 476.902026-02-23: 481.012026-02-24: 487.432026-02-25: 483.052026-02-26: 480.132026-02-27: 496.832026-03-02: 486.032026-03-03: 474.272026-03-04: 477.892026-03-05: 460.822026-03-06: 456.692026-03-09: 460.872026-03-10: 499.172026-03-11: 492.382026-03-12: 478.132026-03-13: 469.342026-03-16: 466.102026-03-17: 462.492026-03-18: 451.592026-03-19: 458.052026-03-20: 454.002026-03-23: 451.242026-03-24: 448.622026-03-25: 454.972026-03-26: 453.742026-03-27: 433.072026-03-30: 443.162026-03-31: 446.542026-04-01: 447.262026-04-02: 438.712026-04-06: 434.302026-04-07: 431.862026-04-08: 443.922026-04-09: 446.782026-04-10: 436.272026-04-13: 440.052026-04-14: 444.282026-04-15: 441.702026-04-16: 435.652026-04-17: 441.202026-04-20: 439.182026-04-21: 436.592026-04-22: 437.672026-04-23: 435.102026-04-24: 430.292026-04-27: 426.012026-04-28: 430.142026-04-29: 423.242026-04-30: 427.382026-05-01: 423.922026-05-04: 429.852026-05-05: 424.362026-05-06: 427.652026-05-07: 425.002026-05-08: 429.822026-05-11: 435.172026-05-12: 448.292026-05-13: 453.062026-05-14: 450.412026-05-15: 436.952026-05-18: 436.582026-05-19: 434.312026-05-20: 430.442026-05-21: 433.542026-05-22: 434.522026-05-26: 435.932026-05-27: 437.222026-05-28: 447.972026-05-29: 447.542026-06-01: 438.402026-06-02: 425.092026-06-03: 428.342026-06-04: 441.742026-06-05: 446.832026-06-08: 442.962026-06-09: 445.772026-06-10: 435.712026-06-11: 445.042026-06-12: 444.932026-06-15: 450.462026-06-16: 453.172026-06-17: 458.992026-06-18: 451.632026-06-22: 466.792026-06-23: 468.422026-06-24: 475.202026-06-25: 480.182026-06-26: 491.342026-06-29: 499.652026-06-30: 496.732026-07-01: 498.012026-07-02: 528.042026-07-06: 529.592026-07-07: 522.252026-07-08: 498.432026-07-09: 496.502026-07-10: 485.392026-07-13: 480.252026-07-14: 476.312026-07-15: 477.082026-07-16: 486.032026-07-17: 485.652026-07-20: 480.502026-07-21: 482.002026-07-22: 472.572026-07-23: 473.092026-07-24: 477.362026-07-27: 479.002026-07-28: 490.392026-07-29: 483.332026-07-30: 481.702026-07-31: 477.102026-08-03: 470.722026-08-04: 478.712026-08-05: 484.832026-08-06: 484.032026-08-07: 496.072026-08-10: 523.912026-08-11: 529.652026-08-12: 525.732026-08-13: 516.442026-08-14: 505.752026-08-17: 515.552026-08-18: 528.192026-08-19: 552.062026-08-20: 540.262026-08-21: 548.052026-08-24: 547.592026-08-25: 552.852026-08-26: 547.292026-08-27: 547.552026-08-28: 541.692026-08-31: 544.522026-09-01: 547.652026-09-02: 556.752026-09-03: 557.962026-09-04: 546.122026-09-08: 528.902026-09-09: 521.122026-09-10: 514.562026-09-11: 515.442026-09-14: 519.512026-09-15: 514.632026-09-16: 513.262026-09-17: 516.342026-09-18: 508.342026-09-21: 510.722026-09-22: 514.992026-09-23: 516.342026-09-24: 522.382026-09-25: 526.192026-09-28: 527.672026-09-29: 526.732026-09-30: 522.812026-10-01: 506.742026-10-02: 504.732026-10-05: 503.502026-10-06: 502.312026-10-07: 505.642026-10-08: 503.252026-10-09: 510.082026-10-12: 507.002026-10-13: 485.222026-10-14: 498.502026-10-15: 508.752026-10-16: 499.742026-10-19: 501.952026-10-20: 514.652026-10-21: 524.522026-10-22: 535.172026-10-23: 523.932026-10-26: 517.492026-10-27: 521.03

Current technical signals nightly scan, 2026-10-27

OBV: Bullish Divergence (Accumulation)MACD: Bullish Weakening

What would change the latest view

  • If Q3 shows net upward EPS revisions resuming and 2027 consensus holds ~$21 while the stock stays near $525, the bearish divergence thesis is wrong and the move has fundamental support
  • A broad, clean povetacicept label with no burdensome REMS and early payer wins would invalidate the sell-the-news framing
  • Journavx/Casgevy tracking materially above the $500M non-CF floor would confirm the diversification re-rate

All calls on VRTX

VRTX Lean bearish
Oct 22, 2026 · Vertex Pharmaceuticals Incorporated · edge 5/10· evidence 7/10

Fundamentals lag the price.

The technical scan is picking up idiosyncratic, catalyst-driven strength (60d correlation to SPY just 0.15, +10.5% 3m vs XBI), not a broad earnings-momentum trend. Revenue fundamentals support the franchise, but EPS revisions are flat-to-down (partly Crinetics dilution through 2028), valuation is at ~25.5x NTM at the upper end of its range, and the two near-term catalysts are…

Entry $524.52 (2026-10-21) 1m vs SPY: -0.2% so far

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